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Pharmacokinetic Concepts Method
After the fifth dose, steady-state peak and trough concentrations were measured and were 40 μg/mL and 3 μg/mL, respectively. Calculate a new vancomycin dose that would provide a steady-state peak of 30 μg/mL and a steady-state trough 10 μg/mL. ZW is a 35-year-old, 150-kg female with an enterococcalendocarditis. A vancomycin dose of 1000 mg every 12 hours was prescribed and expected to achieve steady-state peak and trough concentrations equal to 30 μg/mL and 12 μg/mL, respectively.
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- Nine hours after the second dose of vancomycin 1000 mg every 12 hours, a vancomycin serum concentration equal to 5 μg/mL is measured.
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Online graphing calculator casio, kumon game.online, easy 7th grade math problems and answers, simplifying exponents in square roots, free online KS3 maths calculator papers, south-western fundamentals of accounting course 1 cheats. The one-compartment model intravenous infusion equations used by the program to compute doses indicates that a dose of 1250 mg every 7 days will produce a steady-state peak concentration of 31 μg/mL and a steady-state trough concentration of 10 μg/mL. Loading doses should be considered for patients with creatinine clearance values below 60 mL/min. The administration of a loading dose in these patients will allow achievement of therapeutic concentrations quicker than if maintenance doses alone are given. The advantages of this method are that it is quick and simple.
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- A. Draw a rough sketch of the serum log concentration/time curve by hand, keeping tract of the relative time between the serum concentrations (Figure 5-7).
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